Hydroxylamine Hydrochloride Pharmaceutical Intermediate CAS
Hydroxylamine hydrochloride COA--Jusheng TC.pdf
Molecular Formula: NH2OH·HCL
Physicochemical properties: white crystal, easy deliquescence,
soluble in water and glycerin, insoluble in ethanol and ethyl
Specific gravity: (17/4οC) 1.67
Melting point: 152 οC (disassemble )
Use:This product is mainly used as a reducing agent and imaging
agent, organic synthesis for the preparation of oxime, and also as
the raw material for the synthesis of anti-cancer drugs
(hydroxyurea), sulfa drugs (sinomin), anti-cold medicine and
pesticide(methomyl). It is used as depolarizer In electro-analysis,
in the synthetic rubber industry as non-staining short-term
terminating agent, etc.
Production quality : Performance standards: Q/S BY001 - 2008
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Hydroxylamine Hydrochloride is the hydrochloric acid salt of
hydroxylamine. Hydroxylamine is a biological intermediate in the
nitrification (biological oxidation of ammonia with oxygen into
nitrite) and in the anammox (biological oxidation of nitrite and
ammonium into dinitrogen gas) which are important in the nitrogen
cycle in soil and in wastewater treatment plants.
Uses 1 .
Hydroxylamine and its salts are commonly used as reducing agents in
myriad organic and inorganic reactions. They can also act as
antioxidants for fatty acids.
Conversion from cyclohexanone to caprolactam involving the Beckmann
Rearrangement can be understood with this scheme.
In the synthesis of nylon 6, cyclohexanone is first converted to
its oxime; treatment of this oxime with acid induces the Beckmann
rearrangement to give caprolactam :
The nitrate salt, hydroxylammonium nitrate, is being researched as
a rocket propellant, both in water solution as a monopropellant and
in its solid form as a solid propellant.
Uses 4 .
This has also been used in the past by biologists to introduce
random mutations by switching base pairs from G to A, or from C to
T. This is to probe functional areas of genes to elucidate what
happens if their functions are broken. Nowadays other mutagens are
Uses 5 .
Hydroxylamine can also be used to highly selectively cleave
asparaginyl-glycine peptide bonds in peptides and proteins. It also
bonds to and permanently disables (poisons) heme-containing
enzymes. It is used as an irreversible inhibitor of the
oxygen-evolving complex of photosynthesis on account of its similar
structure to water.
This route also involves the Beckmann Rearrangement, like the
conversion from cyclohexanone to caprolactam.
An alternative industrial synthesis of paracetamol developed by
Hoechst–Celanese involves the conversion of ketone to a ketoxime
Content % ≥
Moisture % ≤
Sulphate % ≤
Fe % ≤
Heavy metal% ≤